SEPTEMBER 4 2016 LAUREN LESLIE KENTUCKY, OWENSBORO It’s the biggest vaping convention in the Midwest and it’s happening in Owensboro. Vape services and advocates all gather together in one place to discuss the latest in the industry.Despite recent mandates and regulations from the Food & Drug Administration the vaping industry is gung-ho going forward. Advocates as well as distributors say the vaping community will band together to defeat the entities that want to see vaping and e-cigarettes go away.Mens Softball Tournament Underway at Deaconess Sports ParkSEPTEMBER 4, 2016 ANN ALBERS INDIANA Another softball tournament is underway at Deaconess Sports Park.Games happening all day for the amateur softball association’s 2016 Northern Men’s Slow-Pitch National Championship.This is the third national tournament to be played in Evansville.Games continue through Monday.Truck Strikes Motorcycle Sending Man to HospitalSEPTEMBER 4, 2016 LAUREN LESLIE EVANSVILLE, INDIANA A wreck on Saturday afternoon sends one man to the hospital. Police say the driver of a maroon pickup truck was turning westbound onto Northwest 1st Street when he struck a motorcycle northbound on court street.The driver of the motorcycle sustained a compound fracture to his left leg. The driver of the pickup truck told officers he could not see the motorcyclist. FacebookTwitterCopy LinkEmail Evansville Police Investigating Two Separate Arson CasesSEPTEMBER 4TH, 2016 BRI WILLIAMS EVANSVILLE, INDIANA In Evansville, Police are investigating two fires happening early Saturday morning. The first in the 900 block of North Main Street.There Police say they found a man walking in the area. No arrests were made but it is being investigated as an arson case.The second fire happening in the 900 block of West Oregon Street. Investigators say they think the fire started in a duplex and caused damage to the siding of the building next door.Officers says smoke could later be seen coming from the roof of the second building so fire crews had to come back to put it out.This case is also being investigated as arson. There are no suspects at this time.Evansville Italian-American Club Helps Earthquake Victims in ItalySEPTEMBER 4TH, 2016 BRI WILLIAMS EVANSVILLE, INDIANA Evansville’s Italian-American Club is cooking with love, responding to help earthquake victims in Italy.Two Evansville chef’s from the Italian-American Club teamed up to make a pasta dish unique to the earthquake region.This Sunday hundreds of people dined at Pangea Kitchen in Evansville supporting the cause. Less than two weeks have passed since a 6.2 magnitude earthquake hit central Italy killing more than 200 people.Organizers say the outpouring of love from the community makes the event a great success.Alessio Lacco says, “We come out with idea to make Amatricana pasta which is really unique for that area and you know offer free pasta and ask for donation.”Enzo Russo says, “Alessio and his team made the pasta fresh, “fusilli” so I make the sauce and we just put it together, and we have a great turnout, we have at least a couple hundred people stop by to help out with this great cause.”The fundraiser brought in nearly $4,000 dollars to help earthquake victims. The money raised will be donated to the Red Cross of Italy.Midwest Vaping Expo Clouds Looming Regulations
To see if these EDIT-induced immune responses could potentially prevent or treat disease, the team repeated their three-week prophylactic injection of EDIT into mice, then inoculated them with lymphoma cells that expressed ovalbumin on their surfaces. The mice that received EDIT had about three-fold slower tumor growth compared with the control group and the group that received free nanoparticles, and had lower numbers of viable cancerous cells. This outcome significantly increased the window of time during which the tumor could be treated before the mice succumbed to the disease. “EDIT essentially is an adjuvant-free vaccine platform. Part of the reason why vaccine development today takes so long is that foreign adjuvants delivered along with an antigen have to go through a full clinical safety trial for each new vaccine,” said Zongmin Zhao, a postdoctoral fellow in the Mitragotri lab and co-first author of the paper. “Red blood cells have been safely transfused into patients for centuries, and their ability to enhance immune responses could make them a safe alternative to foreign adjuvants, increasing the efficacy of vaccines and speed of vaccine creation.”The team is continuing to work on understanding exactly how an immune response that is specific to the antigen presented by EDIT is generated by the spleen’s APCs, and plans to test it with other antigens beyond ovalbumin. They hope to use this additional insight to drive their pursuit of the optimal clinical setting(s) for the technology. “The human body is a treasure trove of elegant solutions to healthcare problems, and while medicine has come a long way in understanding those mechanisms, we are still in the early stages of being able to harness them to improve the length and quality of human life. This research is an exciting step forward toward that goal, and could dramatically change how immune responses are modulated in patients,” said the Wyss Institute’s Founding Director Donald Ingber, who is also the Judah Folkman Professor of Vascular Biology at Harvard Medical School and Boston Children’s Hospital, and professor of bioengineering at SEAS.Additional authors of the paper include Vinu Krishnan, Daniel C. Pan, Yongsheng Gao, and Abhirup Mandal from the Wyss Institute and SEAS; Alexandra Fehnel from SEAS, and Vladimir Muzykantov from the Perelman School of Medicine at the University of Pennsylvania. This research was supported by the Wyss Institute at Harvard University and the National Institutes of Health under grant # 1R01HL143806-01. Related Biomaterial-based vaccine eliminates acute myeloid leukemia in mice Designing a coronavirus vaccine A solid vaccine for liquid tumors Researchers prepare for next year and beyond Team at Harvard plans to launch clinical trial in fall Red blood cells do more than shuttle oxygen from our lungs to our organs: they also help the body fight off infections by capturing pathogens on their surfaces, neutralizing them, and presenting them to immune cells in the spleen and liver. A team of researchers from Harvard’s Wyss Institute for Biologically Inspired Engineering and John A. Paulson School of Engineering and Applied Sciences (SEAS) has harnessed this innate ability to build a platform technology that uses red blood cells to deliver antigens to antigen-presenting cells (APCs) in the spleen, generating an immune response. This approach successfully slowed the growth of cancerous tumors in mice, and could also be used as a biocompatible adjuvant for a variety of vaccines. The technology, called Erythrocyte-Driven Immune Targeting (EDIT), is reported this week in PNAS.“The spleen is one of the best organs in the body to target when generating an immune response, because it is one of the few organs where red and white blood cells naturally interact,” said senior author Samir Mitragotri, a Wyss Core Faculty member who is also the Hiller Professor of Bioengineering and Hansjörg Wyss Professor of Biologically Inspired Engineering at SEAS. “Red blood cells’ innate ability to transfer attached pathogens to immune cells has only recently been discovered, and this study unlocks the door to an exciting array of future developments in the field of using human cells for disease treatment and prevention.”A ‘check me out’ signalUsing red blood cells as delivery vehicles for drugs is not a new idea, but the vast majority of existing technologies target the lungs, because their dense network of capillaries causes cargoes to shear off of red blood cells as they squeeze through the tiny vessels. Mitragotri’s research team first needed to figure out how to get antigens to stick to red blood cells strongly enough to resist shearing off and reach the spleen. They coated polystyrene nanoparticles with ovalbumin, an antigenic protein known to cause a mild immune response, then incubated them with mouse red blood cells. The ratio of 300 nanoparticles per blood cell resulted in the greatest number of nanoparticles bound to the cells, retention of about 80 percent of the nanoparticles when the cells were exposed to the shear stress found in lung capillaries, and moderate expression of a lipid molecule called phosphatidyl serine (PS) on the cells’ membranes.,“A high level of PS on red blood cells is essentially an ‘eat me’ signal that causes them to be digested by the spleen when they are stressed or damaged, which we wanted to avoid. We hoped that a lower amount of PS would instead temporarily signal ‘check me out’ to the spleen’s APCs, which would then take up the red blood cells’ antigen-coated nanoparticles without the cells themselves getting destroyed,” said Anvay Ukidve, a graduate student in the Mitragotri lab and co-first author of the paper.To test that hypothesis, the team injected red blood cells coated with their nanoparticles into mice, then tracked where they accumulated in their bodies. Twenty minutes after injection, more than 99 percent of the nanoparticles had been cleared from the animals’ blood, and more nanoparticles were present in their spleens than their lungs. The higher nanoparticle accumulation in the spleen persisted for up to 24 hours and the number of EDIT red blood cells in the circulation remained unchanged, showing that the red blood cells had successfully delivered their cargoes to the spleen without being destroyed. Effective, adjuvant-free vaccinesHaving confirmed that their nanoparticles were successfully delivered to the spleen in vivo, the researchers next evaluated whether the antigens on the nanoparticles’ surfaces induced an immune response. Mice were injected with EDIT once a week for three weeks, and then their spleen cells were analyzed. Treated mice displayed eight-fold and 2.2-fold more T cells displaying the delivered ovalbumin antigen than mice that were given “free” nanoparticles or were untreated, respectively. Mice treated with EDIT also produced more antibodies against ovalbumin in their blood than either of the other groups of mice. “[Red blood cells’] ability to enhance immune responses could make them a safe alternative to foreign adjuvants, increasing the efficacy of vaccines and speed of vaccine creation.” — Zongmin Zhao, co-first author Global race to a COVID-19 vaccine
Employers who help employees pay off student loans are rare.According to the Society for Human Resource Management (SHRM), only about 3% of companies in the US offer to help employees chip away at student loans. Most of the employees currently receiving this benefit work in the public sector, such as nurses, teachers, and lawyers.The limited number of companies offering this benefit may be in part because, unlike 401(k) contributions and tuition reimbursement (for employees who pursue degrees sponsored by their employer), student loan debt assistance is not currently tax-deductible. In fact, the amount gets taxed as income for the employee.But a new study from personal finance site NerdWallet finds more companies in the private sector are contributing to student debt repayment for the first time. So companies that help tackle loans are rare … but they exist. continue reading » 19SHARESShareShareSharePrintMailGooglePinterestDiggRedditStumbleuponDeliciousBufferTumblr
By Frederick HalleyTORONTO, Canada — After claiming the runner-up spot for four consecutive years, including a narrow one-run loss to Our Own in last year’s final, Guyana Sports Club (GSC) broke the jinx on Sunday when they emerged winners of the Ontario Masters Softball Cricket Clubs (OMSCC) Division One tournament at St Bede’s ground, Scarborough.Division Two champions Royals celebrate their win.Entering the final as the number four seed, GSC turned back the challenge of second seeded East Coast Hustlers after earlier creating a stir by trouncing favourites and defending champions Our Own in the semi-final the previous weekend.The Division Two final saw Royals live up to their number one billing in a tense two-run victory over Miracles who were fourth in the standings in their division.Eager to enter winners’ row after coming close on a few occasions, GSC seemed a determined bunch and from the word go had Hustlers on the back foot, ripping through the top order which included the likes of the team’s leading run-getter Rovendra Madholall, who was brilliantly bowled by Terry Mathura in the third over after his team was inserted to take first strike.By the end of the 10th over, Hustlers were reduced to 38 for six and despite putting up some resistance in the remaining 10, an insufficient 99 all out was all they could muster in 19.2 overs.Abinash Ramnarayan (48) was the only batsman to offer any resistance, hitting three fours and a six while Avinash Singh supported with 17. For GSC, Farouk Inshan claimed three for 10 from three overs and Khemraj Budhai two for seven from 1.2.Despite losing Inshan with just 12 on the board, GSC cruised to an emphatic seven-wicket victory in 13.4 overs with Jito Narine blasting three sixes and four fours in an unbeaten 42 and also earning the Most Valuable Player (MVP) for his side. Skipper Rakesh Dyal finished with two for 18 from three overs and Ramkarran Seegobin one for five runs from one. Ramnarayan was voted MVP for Hustlers.In a more competitive Division Two final, Miracles almost pulled off a miraculous win after being set a challenging 178 for victory in their allotted 20 overs.Keeping pace with the required target throughout their innings, Miracles needed seven off the last over but were left high and dry on 175 for five, after a brilliant last over from Suresh Keso which yielded just four runs.MVP Matbar Singh, who was mainly responsible for his team reaching the final following a last-ball boundary in the semi-final versus Ramblers, was again among the runs, slamming four fours and a six in a top score of 44 while Hazari Girdhari made 33. Extras contributed a healthy 62, including some 40 wides. Four run-outs did little to help Miracles’ cause.When Royals batted, they were indebted to half-centuries from MVP Deonarine Sukhoo (55) and Abdool Azeeze (54) as they reached a formidable 177 for five in their 20 overs. Deonarine struck six fours and two sixes while Azeeze counted six sixes and a four in his knock. Rabindranauth Persaud claimed two for 16.Both finals once again attracted hundreds of spectators and at the presentation ceremony, OMSCC president Azeem Khan lauded the efforts of the participating teams and the commitment shown throughout the season. The OMSCC presentation dinner and dance is set for Saturday, October 15.